ABSTRACT

Pediatric cancer survivors (PCS) experience functional difficulties and brain alterations. However, little is known about cerebral perfusion and its relationship to functional outcome (cognitive and motor performance) in PCS. We examined cerebral blood flow (CBF) in non-brain tumor PCS and the associations between CBF and age, as well as functional outcome. Forty PCS and 40 age-comparable controls were included. CBF did not differ between PCS and controls. CBF decreased with age only in controls. In PCS, CBF was associated with functional outcome. Our data indicate an altered relationship between age and CBF in survivors, with stronger brain-behavior mechanisms after cancer.

摘要

小儿癌症幸存者 (PCS) 会经历功能困难和大脑改变。然而，人们对 PCS 中的脑灌注及其与功能结果（认知和运动表现）的关系知之甚少。我们检查了非脑肿瘤 PCS 的脑血流量 (CBF) 以及 CBF 与年龄以及功能结果之间的关联。包括 40 个 PCS 和 40 个年龄可比的对照。PCS 和对照之间的 CBF 没有差异。仅在对照组中，CBF 随着年龄的增长而下降。在 PCS 中，CBF 与功能结果相关。我们的数据表明，幸存者的年龄和 CBF 之间的关系发生了变化，癌症后大脑行为机制更强。