The last 10 years have seen a major shift in management of large vessel ischemic stroke with changes towards ever-expanding use of reperfusion therapies (intravenous thrombolysis and mechanical thrombectomy). These strategies ‘open the door’ to acute therapeutics for ischemic tissue, and we should investigate novel therapeutic approaches to enhance survival of recently reperfused brain. Key insights into new approaches have been provided through translational research models and preclinical paradigms, and through detailed research on ischemic mechanisms. Additional recent clinical trials offer exciting salvos into this new strategy of pairing reperfusion with neuroprotective therapy. This pairing strategy can be employed using drugs that have shown neuroprotective efficacy; neurointerventionalists can administer these during or immediately after reperfusion therapy. This represents a crucial moment when we emphasize reperfusion, and have the technological capability along with the clinical trial experience to lead the way in multiprong approaches to stroke treatment.

中文翻译：

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现在大门已经打开：神经介入医生缺血性中风药物治疗的最新进展

过去 10 年，大血管缺血性卒中的治疗发生了重大转变，不断扩大再灌注疗法（静脉溶栓和机械取栓）的使用。这些策略为缺血组织的急性治疗“打开了大门”，我们应该研究新的治疗方法来提高最近再灌注大脑的存活率。通过转化研究模型和临床前范式以及对缺血机制的详细研究，提供了对新方法的关键见解。最近的其他临床试验为这种将再灌注与神经保护治疗相结合的新策略提供了令人兴奋的支持。这种配对策略可以与已显示出神经保护功效的药物一起使用；神经介入医师可以在再灌注治疗期间或之后立即进行这些治疗。这是一个关键时刻，我们强调再灌注，并拥有技术能力和临床试验经验，以引领多管齐下的中风治疗方法。