Nanofibers (NFs) with practical drug-loading capacities, high stability, and controllable release have caught the attention of investigators due to their potential applications in on-demand drug delivery devices. Developing novel and efficient multidisciplinary management of locoregional cancer treatment through the design of smart NF-based systems integrated with combined chemotherapy and hyperthermia could provide stronger therapeutic advantages. On the other hand, implanting directly at the tumor area is a remarkable benefit of hyperthermia NF-based drug delivery approaches. Hence, implantable smart hyperthermia NFs might be very hopeful for tumor treatment in the future and provide new avenues for developing highly efficient localized drug delivery systems. Indeed, features of the smart NFs lead to the construction of a reversibly flexible nanostructure that enables hyperthermia and facile switchable release of antitumor agents to eradicate cancer cells. Accordingly, this study covers recent updates on applications of implantable smart hyperthermia NFs regarding their current scope and future outlook.

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用于癌症治疗的植入式智能热疗纳米纤维：挑战与机遇

具有实用载药能力、高稳定性和可控释放的纳米纤维（NF）因其在按需给药装置中的潜在应用而引起了研究人员的关注。通过设计基于 NF 的智能系统并结合化疗和热疗，开发新颖有效的局部癌症治疗多学科管理可以提供更强的治疗优势。另一方面，直接植入肿瘤区域是基于热疗 NF 的药物输送方法的显着优点。因此，植入式智能热疗神经网络在未来的肿瘤治疗中可能充满希望，并为开发高效的局部药物输送系统提供新途径。事实上，智能纳米纤维的特征导致了可逆柔性纳米结构的构建，该结构能够实现高温和轻松切换释放抗肿瘤药物以根除癌细胞。因此，本研究涵盖了植入式智能热疗 NF 应用的最新更新，涉及其当前范围和未来前景。