Cancer ranks as a leading threat to human life and health. Compared to conventional cancer treatments, phototheranostics shares the advantages of integrated diagnosis and therapy, outstanding therapeutic performance and good controllability. Amid diverse phototheranostic agents, small organic luminogens with aggregation-induced emission (AIEgen) tendency show predominant advantages in terms of superior photostability, large Stokes shifts, and boosted theranostic capacity as aggregates. In the past two decades, AIE-active materials have demonstrated formidable applications in disease theranostics, especially for tumors. This review mainly highlights the recent advances of orthotopic tumor phototheranostics mediated by AIEgens with a classification of different organs. Additionally, a brief discussion of current bottlenecks and future directions is outlined. We believe this review can deepen the understanding and spur more innovations on tumor theranostics by employing AIEgens.

中文翻译：

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用于原位肿瘤光治疗的 AIE 活性材料的最新进展

癌症被列为对人类生命和健康的主要威胁。与传统癌症治疗相比，光治疗具有诊疗一体化、治疗效果突出、可控性好等优点。在多种光治疗剂中，具有聚集诱导发射（AIEgen）趋势的小型有机发光剂在优异的光稳定性、大斯托克斯位移和作为聚集体时提高的治疗诊断能力方面显示出显着的优势。在过去的二十年中，AIE 活性材料在疾病治疗诊断中，尤其是肿瘤治疗中，展现出了强大的应用前景。本综述主要重点介绍了AIEgens介导的针对不同器官分类的原位肿瘤光疗的最新进展。此外，还概述了当前瓶颈和未来方向的简要讨论。我们相信这篇综述可以通过采用 AIEgens 加深理解并激发肿瘤治疗诊断学的更多创新。