Objective

The aim of this study was to investigate the association between atrial fibrillation (AF) and new-onset myocardial infarction (MI) among a working-age population in an industrial city of North China.

Methods

In total 77,670 participants aged under 60 years were selected for this cohort study. Participants were divided into an AF group (n = 121) and a non-AF group (n = 74,565) based on their medical histories. Thereafter, 121 participants from the AF group were propensity-matched with 363 participants from the non-AF group. All participants were followed up from June 2006 to December 2020; new-onset MI was regarded as the endpoint of this study. Multivariate Cox proportional hazards regression analysis models were designed to analyze the correlation between AF and new-onset MI.

Results

During the 14-year follow-up, eight cases of new-onset MI were documented in the AF group, while five cases were documented in the non-AF group. The cumulative incidence of new-onset MI in the AF group (7.40%) was markedly higher than in the non-AF group (1.41%; p < 0.001). Atrial fibrillation was associated with an increased risk of new-onset MI in both univariate analysis (hazard ratio: 5.202, 95% confidence interval [CI]: 1.700–15.913) and multivariable-adjusted analysis (hazard ratio: 5.335, 95% CI: 1.683–16.910).

Conclusion

Atrial fibrillation increased the risk of new-onset MI amongst working-age individuals in an industrial city of North China.

中文翻译：

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心房颤动增加工作年龄人群新发心肌梗死的风险：一项倾向匹配研究

客观的

本研究的目的是调查华北某工业城市劳动年龄人口中心房颤动（AF）与新发心肌梗死（MI）之间的关联。

方法

这项队列研究总共选择了 77,670 名 60 岁以下的参与者。 根据病史，参与者被分为 AF 组 ( n  = 121) 和非 AF 组 ( n = 74,565)。此后，来自 AF 组的 121 名参与者与来自非 AF 组的 363 名参与者进行了倾向匹配。2006年6月至2020年12月对所有参与者进行随访；新发心肌梗死被视为本研究的终点。设计多变量 Cox 比例风险回归分析模型来分析 AF 与新发 MI 之间的相关性。

结果

在 14 年的随访期间，AF 组记录了 8 例新发 MI 病例，而非 AF 组记录了 5 例。AF 组新发 MI 的累积发生率 (7.40%) 显着高于非 AF 组 (1.41%；p  < 0.001)。在单变量分析（风险比：5.202，95%置信区间[CI]：1.700-15.913）和多变量调整分析（风险比：5.335，95% CI： 1.683–16.910）。

结论

心房颤动增加了华北工业城市工作年龄人群新发心肌梗死的风险。