This research focuses on investigating the changes of oral flora, inflammatory factors, and immune function indicators in patients with chronic periodontitis (CP) and their clinical significances. Clinical indices such as gingival index (GI) and sulcus bleeding index (SBI) of the study subjects were recorded. The levels of oral flora, inflammatory factors and T lymphocyte subsets in gingival crevicular fluid (GCF) of the study subjects were measured. To analyze the correlation between GI and gingival SBI and oral flora, inflammatory factors, and immune function indicators, Pearson correlation analysis was performed. Porphyromonas gingivalis, Streptococcus digestiveis, Prevotella intermedia, Veronococcus, tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), IL-8, CD3⁺, CD4⁺, and CD4⁺/CD8⁺ had a positive correlation with GI and SBI, while IL-10 and CD8⁺ were negatively correlated with GI and SBI. Oral flora, inflammatory factors and immune function indicators levels are largely elevated in patients with CP and they are correlated with CP clinical indicators.

中文翻译：

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慢性牙周炎患者口腔菌群、炎症因子及免疫功能指标的变化及其临床意义

本研究重点探讨慢性牙周炎（CP）患者口腔菌群、炎症因子、免疫功能指标的变化及其临床意义。记录研究对象的牙龈指数（GI）和龈沟出血指数（SBI）等临床指标。测量研究对象龈沟液（GCF）中口腔菌群、炎症因子和T淋巴细胞亚群的水平。为了分析GI和牙龈SBI与口腔菌群、炎症因子、免疫功能指标的相关性，进行Pearson相关分析。牙龈卟啉单胞菌、消化链球菌、中间普雷沃氏菌、维罗球菌、肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）、IL-8、CD3 ⁺、CD4 ⁺、CD4 ⁺ /CD8 ⁺呈正相关与GI和SBI呈负相关，而IL-10和CD8 ⁺与GI和SBI呈负相关。CP患者口腔菌群、炎症因子和免疫功能指标水平显着升高，且与CP临床指标相关。