This review described the preparation of 2-(piperazin-1-yl) quinoline derivatives from 2- haloquinolines and anilides, which underwent alkylation, arylation, acylation, and reductive amination to form the 2-piprazinoquinolines. 2-(Piperazin-1-yl) quinoline used as building blocks for the synthesis of polyfunctionalized heterocyclic compounds with pharmacological interest.

中文翻译：

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2-(哌嗪-1-基)喹啉的化学进展（第四部分）

该综述描述了从2-卤代喹啉和苯胺制备2-(哌嗪-1-基)喹啉衍生物，该衍生物经过烷基化、芳基化、酰化和还原胺化形成2-哌嗪喹啉。2-(哌嗪-1-基)喹啉用作合成具有药理学意义的多官能化杂环化合物的结构单元。