OBJECTIVE The primary aim of this qualitative study was to delineate psychological mechanisms of change in the first randomized controlled trial of psilocybin-assisted psychotherapy to treat alcohol use disorder (AUD). Theories regarding psychological processes involved in psychedelic therapy remain underdeveloped. METHOD Participants (N = 13) mostly identified as non-Hispanic and White, with approximately equal proportions of cisgender men and women. Participants engaged in semistructured interviews about their subjective experiences in the study. Questions probed the nature of participants' drinking before and after the study as well as coping patterns in response to strong emotions, stress, and cravings for alcohol. Verbatim transcripts were coded using Dedoose software, and content was analyzed with interpretive phenomenological analysis. RESULTS Participants reported that the psilocybin treatment helped them process emotions related to painful past events and helped promote states of self-compassion, self-awareness, and feelings of interconnectedness. The acute states during the psilocybin sessions were described as laying the foundation for developing more self-compassionate regulation of negative affect. Participants also described newfound feelings of belonging and an improved quality of relationships following the treatment. CONCLUSION Our results support the assertion that psilocybin increases the malleability of self-related processing, and diminishes shame-based and self-critical thought patterns while improving affect regulation and reducing alcohol cravings. These findings suggest that psychosocial treatments that integrate self-compassion training with psychedelic therapy may serve as a useful tool for enhancing psychological outcomes in the treatment of AUD. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

---

裸盖菇素辅助治疗酒精使用障碍的自我慈悲和情感调节的报告：解释性现象学分析。

目的 这项定性研究的主要目的是描绘第一个用裸盖菇素辅助心理治疗治疗酒精使用障碍 (AUD) 的随机对照试验中的心理变化机制。关于迷幻治疗涉及的心理过程的理论仍然不发达。方法 参与者 (N = 13) 大多为非西班牙裔和白人，其中顺性别男性和女性的比例大致相等。参与者就他们在研究中的主观经历进行了半结构化访谈。问题探讨了参与者在研究前后饮酒的性质，以及应对强烈情绪、压力和对酒精的渴望的应对模式。使用 Dedoose 软件对逐字记录进行编码，并使用解释现象学分析对内容进行分析。结果参与者报告说，裸盖菇素治疗帮助他们处理与过去痛苦事件相关的情绪，并有助于促进自我慈悲、自我意识和相互联系的感觉。裸盖菇素治疗期间的急性状态被描述为发展对负面情绪的更多自我同情调节奠定了基础。参与者还描述了治疗后新发现的归属感和人际关系质量的改善。结论我们的结果支持这样的论点：裸盖菇素增加了自我相关处理的可塑性，减少了基于羞耻和自我批评的思维模式，同时改善了情感调节并减少了对酒精的渴望。这些发现表明，将自我慈悲训练与迷幻疗法相结合的心理社会治疗可能成为增强 AUD 治疗心理结果的有用工具。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。