Addiction is a global concern with a high relapse rate and without effective therapeutic options. Developing new effective therapeutic strategies is impossible without discovering the disease's neurobiological basis. The present systematic review aimed to comprehensively recognize and discuss the role of local field potentials from brain areas essential in forming and storing context-drug/food associations following the conditioned place preference (CPP) paradigm as a popular animal model of reward and addiction. Qualified studies were incorporated by a broad search of four databases, including Web of Science, Medline/PubMed, Embase, and ScienceDirect, in July 2022, and they were evaluated via appropriate methodological quality assessment tools. The current study found that drug-seeking behavior in different stages of the CPP paradigm is accompanied by alterations in neural oscillatory activity and adaptations in connectivity among various areas such as the hippocampus, nucleus accumbens, basolateral amygdala, and prelimbic area, intensely engaged in reward-related behaviors. These findings need to be extended by more future advanced studies to finally recognize the altered oscillatory activity patterns of large groups of cells in regions involved in reward-context associations to improve clinical strategies such as neuromodulation approaches to modify the abnormal electrical activity of these critical brain regions and their connections for treating addiction and preventing drug/food relapse in abstinent patients.

中文翻译：

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临床前研究中条件位置偏好任务期间局部场潜在适应性的系统评价

成瘾是一个全球性问题，其复发率很高，而且没有有效的治疗方案。如果不发现该疾病的神经生物学基础，就不可能开发新的有效治疗策略。本系统综述旨在全面认识和讨论大脑区域局部场电位在形成和存储背景药物/食物关联中所必需的作用，遵循条件性位置偏好（CPP）范式作为流行的奖励和成瘾动物模型。2022 年 7 月，通过对 Web of Science、Medline/PubMed、Embase 和 ScienceDirect 等四个数据库的广泛检索，纳入了合格的研究，并通过适当的方法学质量评估工具对这些研究进行了评估。目前的研究发现，CPP范式不同阶段的药物寻求行为伴随着神经振荡活动的改变以及海马体、伏核、基底外侧杏仁核和前边缘区等各区域之间连接的适应，这些区域与奖励密切相关相关行为。这些发现需要通过未来更多的高级研究来扩展，以最终认识到涉及奖励-背景关联的区域中大群细胞的振荡活动模式的改变，以改进临床策略，例如改变这些关键大脑的异常电活动的神经调节方法治疗成瘾和预防戒毒患者药物/食物复发的区域及其联系。