Significance Transcranial photobiomodulation (tPBM) is a noninvasive neuromodulation method that facilitates the improvement of human cognition. However, limited information is available in the literature on the wavelength- and site-specific effects of prefrontal tPBM. Moreover, 2-channel broadband near-infrared spectroscopy (2-bbNIRS) is a new approach for quantifying infra-slow oscillations (ISO; 0.005 to 0.2 Hz) of neurophysiological networks in the resting human brain in vivo. Aim We aim to prove the hypothesis that the hemodynamic and metabolic activities of the resting prefrontal cortex are significantly modulated by tPBM and that the modulation is wavelength- and site-specific in different ISO bands. Approach Noninvasive 8-min tPBM with an 800- or 850-nm laser or sham was delivered to either side of the forehead of 26 healthy young adults. A 2-bbNIRS unit was used to record prefrontal ISO activity 7 min before and after tPBM/sham. The measured time series were analyzed in the frequency domain to determine the coherence of hemodynamic and metabolic activities at each of the three ISO frequency bands. Sham-controlled coherence values represent tPBM-induced effects on neurophysiological networks. Results Prefrontal tPBM by either wavelength and on either lateral side of the forehead (1) increased ipsilateral metabolic-hemodynamic coupling in the endogenic band and (2) desynchronized bilateral activity of metabolism in the neurogenic band and vascular smooth-muscle hemodynamics in the myogenic band. Site-specific effects of laser tPBM were also observed with significant enhancement of bilateral hemodynamic and metabolic connectivity by the right prefrontal 800-nm tPBM. Conclusions Prefrontal tPBM can significantly modulate neurophysiological networks bilaterally and coupling unilaterally in the human prefrontal cortex. Such modulation effects are site- and wavelength-specific for each ISO band.

中文翻译：

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800 和 850 nm 前额经颅光生物调节对年轻人前额双侧连接和单侧耦合的位点特异性影响。

意义 经颅光生物调节 (tPBM) 是一种无创神经调节方法，可促进人类认知的改善。然而，关于前额叶 tPBM 的波长和位点特定影响的文献中提供的信息有限。此外，2 通道宽带近红外光谱 (2-bbNIRS) 是一种新方法，用于量化体内静息人脑神经生理网络的亚慢速振荡（ISO；0.005 至 0.2 Hz）。目的 我们的目的是证明静息前额叶皮层的血流动力学和代谢活动受 tPBM 显着调节并且该调节在不同 ISO 波段中具有波长和位点特异性的假设。方法 将使用 800 或 850 纳米激光或假手术的无创 8 分钟 tPBM 传送到 26 名健康年轻人前额的两侧。使用 2-bbNIRS 单元记录 tPBM/sham 前后 7 分钟的前额叶 ISO 活动。在频域中分析测量的时间序列，以确定三个 ISO 频带中每个频带的血液动力学和代谢活动的一致性。假控制的相干值代表 tPBM 对神经生理网络的影响。结果 任一波长和前额两侧的前额 tPBM (1) 增加内源性带中的同侧代谢-血流动力学耦合和 (2) 神经源性带中双侧代谢活动和肌源性带中血管平滑肌血流动力学的去同步化. 还观察到激光 tPBM 的位点特异性效应，右前额叶 800 nm tPBM 显着增强了双侧血流动力学和代谢连通性。结论 前额叶 tPBM 可以显着调节人类前额叶皮层的双侧神经生理网络和单侧耦合。这种调制效果对于每个 ISO 波段都是特定于位置和波长的。