Objective

To explore the effects of short-term moderate-intensity cycle ergometer and aerobic calisthenics training on drug craving and brain activity.

Methods

Forty female methamphetamine (MA)-dependent patients were randomly assigned to receive 30 min of either moderate-intensity cycle ergometer or aerobic calisthenics training. Before and after exercise, drug-cue exposure task was used to assess changes in subjective drug craving, and functional near-infrared spectroscopy (fNIRS) was used to assess activation of prefrontal cortex.

Results

After the intervention, drug craving was significantly decreased in both groups, and activation of frontal polar area (FPA) was significantly decreased in the cycle ergometer group. Functional connectivity between right dorsolateral prefrontal cortex (DLPFC) and FPA in the aerobic calisthenics group was significantly reduced. Pre-exercise levels of drug craving correlated positively with FPA activation.

Conclusion

Both short-term moderate-intensity cycle ergometer and aerobic calisthenics training effectively reduced subjective drug craving in female MA-dependent patients. Cycle ergometer training mainly decreased neural activity in FPA, and likely suppressed drug craving by reducing the episodic memory and pleasure experience of drug-related cues. Aerobic calisthenics training reduced functional connectivity between FPA and right DLPFC, and likely helped subjects reduce the motivation for drug-related behavior and inhibit drug craving.

中文翻译：

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不同运动方式对女性甲基苯丙胺依赖患者药物渴望的影响：来自行为和 fNIRS 的证据

客观的

探讨短期中等强度自行车测力计和有氧健美操训练对毒瘾和大脑活动的影响。

方法

四十名女性甲基苯丙胺 (MA) 依赖患者被随机分配接受 30 分钟的中等强度自行车测力计或有氧健美操训练。运动前后，药物提示暴露任务用于评估主观药物渴望的变化，功能性近红外光谱 (fNIRS) 用于评估前额叶皮层的激活。

结果

干预后，两组对药物的渴望均显着降低，自行车测力计组的额极区 (FPA) 激活显着降低。有氧体操组右侧背外侧前额叶皮层 (DLPFC) 和 FPA 之间的功能连接显着降低。运动前的药物渴望水平与 FPA 激活呈正相关。

结论

短期中等强度循环测力计和有氧健美操训练均有效降低了女性 MA 依赖患者的主观药物渴望。自行车测力计训练主要降低 FPA 的神经活动，并可能通过减少与药物相关线索的情景记忆和愉悦体验来抑制药物渴望。有氧健美操训练降低了 FPA 和右侧 DLPFC 之间的功能连接，并可能帮助受试者降低药物相关行为的动机并抑制药物渴望。