The study of cellular immune responses in animal disease models demands detailed knowledge of development, function, and regulation of immune cells, including natural killer (NK) cells. Listeria monocytogenes (LM) bacterium has been explored in a large area of research fields, including the host pathogen interaction. Although the importance role of NK cells in controlling the first phase of LM burden has been investigated, the interaction between NK cells and infected cells in details are far from being comprehended. From in vivo and in vitro experiments, we can drive several important pieces of knowledge that hopefully contribute to illuminating the intercommunication between LM-infected cells and NK cells. Experimental studies performed in rats revealed that certain NK cell ligands are influenced in LM-infected cells. These ligands include both classical- and non-classical MHC class I molecules and C-type lectin related (Clr) molecules that are ligands for Ly49- and NKR-P1 receptors respectively. Interaction between these receptors:ligands during LM infection, demonstrated stimulation of rat NK cells. Hence, these studies provided additional knowledge to the mechanisms NK cells utilise to recognise and respond to LM infection outlined in the current review.

中文翻译：

---

自然杀伤细胞对单核细胞增多性李斯特菌感染的识别：通过大鼠实验研究了解完整情况。

动物疾病模型中细胞免疫反应的研究需要详细了解免疫细胞（包括自然杀伤 (NK) 细胞）的发育、功能和调节。单核细胞增生李斯特氏菌 (LM) 细菌已在广泛的研究领域进行了探索，包括与宿主病原体的相互作用。尽管 NK 细胞在控制 LM 负荷第一阶段的重要作用已被研究，但 NK 细胞与感染细胞之间的相互作用的细节还远未被理解。通过体内和体外实验，我们可以得出一些重要的知识，希望有助于阐明 LM 感染细胞和 NK 细胞之间的相互交流。在大鼠中进行的实验研究表明，某些 NK 细胞配体在 LM 感染的细胞中受到影响。这些配体包括经典和非经典 MHC I 类分子以及 C 型凝集素相关 (Clr) 分子，它们分别是 Ly49 和 NKR-P1 受体的配体。这些受体：LM 感染过程中配体之间的相互作用，显示出对大鼠 NK 细胞的刺激。因此，这些研究为 NK 细胞识别和响应当前综述中概述的 LM 感染的机制提供了更多知识。