We investigated the incidence and risk factors of seizures related to progressive multifocal leukoencephalopathy (PML) in Korean patients infected with HIV. Of the 34 patients, 14 (41.2%) developed epileptic seizures during a median follow-up of 82 months. The median time from PML diagnosis to seizure onset was 44 months, ranging from 0 to 133 months. Patients with PML who developed seizures more commonly had cognitive impairment and multiple or diffuse lesions on brain MRI. These findings highlight the increased seizure risk among HIV-infected patients with PML at any stage of the disease, particularly in cases with extensive involvement.

我们调查了韩国 HIV 感染患者与进行性多灶性白质脑病 (PML) 相关的癫痫发作的发生率和危险因素。在 34 名患者中，14 名（41.2%）在中位随访 82 个月期间出现癫痫发作。从 PML 诊断到癫痫发作的中位时间为 44 个月，范围为 0 至 133 个月。发生癫痫发作的 PML 患者更常见有认知障碍，脑部 MRI 表现为多发性或弥漫性病变。这些发现强调了患有 PML 的 HIV 感染患者在疾病任何阶段的癫痫发作风险增加，特别是在广泛受累的病例中。