Background HIV is a risk factor for the development of chronic kidney disease. People with chronic kidney disease in the state sector are likely to be prescribed continuous ambulatory peritoneal dialysis (CAPD). Previous studies have raised concern about the safety of CAPD in people living with HIV (PLWH) compared to HIV-negative patients. Objectives To compare the risk of peritonitis, and modality and patient survival by HIV status in patients receiving CAPD at Helen Joseph Hospital. Method A retrospective study of patients receiving CAPD between 01 January 2007 and 31 December 2017 was undertaken. Five-year patient and modality survival were modelled for PLWH and HIV-negative subgroups and analysed using the log-rank test; the effect of CD4 count, HIV viral load, and duration of antiretroviral therapy on these parameters in PLWH were additionally modelled using the Cox Proportional Hazards technique. Results Eighty-four patients, comprising of 21 PLWH and 63 HIV-negative patients, were analysed. No difference was observed in the proportion of patients who had at least one episode of peritonitis between PLWH (61.2%) and HIV-negative patients (63.5%) (P = 0.547). A trend towards increased risk of peritonitis due to Gram-negative organisms in PLWH was noted (odds ratio: 3.20, 95% confidence interval: 0.86-11.9, P = 0.083). No difference was observed in 5-year patient or modality survival on CAPD between PLWH (log-rank P = 0.161) and HIV-negative patients (log-rank P = 0.240). Conclusion People living with HIV should not be excluded from CAPD as a mode of kidney replacement therapy (KRT).

中文翻译：

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在 Helen Joseph 肾脏病房接受腹膜透析的 HIV 阳性成人的生存结果。

背景 HIV 是慢性肾病发展的危险因素。国家部门的慢性肾病患者很可能会接受持续性非卧床腹膜透析 (CAPD)。与 HIV 阴性患者相比，先前的研究引起了人们对 CAPD 在 HIV 感染者 (PLWH) 中的安全性的担忧。目的 比较在海伦约瑟夫医院接受 CAPD 的患者腹膜炎的风险、方式和患者存活率（按 HIV 状态）。方法 对 2007 年 1 月 1 日至 2017 年 12 月 31 日期间接受 CAPD 的患者进行了回顾性研究。对 PLWH 和 HIV 阴性亚组的五年患者和模式生存建模，并使用对数秩检验进行分析；CD4 计数、HIV 病毒载量的影响，使用 Cox 比例风险技术对 PLWH 中这些参数的抗逆转录病毒治疗和持续时间进行了额外建模。结果 分析了 84 名患者，其中包括 21 名 PLWH 和 63 名 HIV 阴性患者。PLWH (61.2%) 和 HIV 阴性患者 (63.5%) 之间至少发生过一次腹膜炎的患者比例没有差异 (P = 0.547)。注意到 PLWH 中革兰氏阴性菌导致腹膜炎风险增加的趋势（比值比：3.20，95% 置信区间：0.86-11.9，P = 0.083）。在 PLWH（对数秩 P = 0.161）和 HIV 阴性患者（对数秩 P = 0.240）之间，CAPD 的 5 年患者或方式存活率没有差异。结论 不应将 HIV 感染者排除在 CAPD 作为肾脏替代疗法 (KRT) 模式之外。