Glioblastoma multiforme (GBM) is an aggressive and fatal brain tumor that tends to occur in older adults and has several subtypes. The fact that the mechanisms of initiation and progression of glioblastoma are not yet known is an obstacle to the treatment of the disease. For this reason, studies have been carried out in recent years to develop new therapeutic approaches. Photodynamic therapy (PDT) is a procedure that has been approved and is considered safe in most clinical trials. With the help of a photosensitizer (PS), tumor growth regression is promoted, aiming to prolong the survival of patients with glioma progression. It is extremely important to conduct studies focused on the development, application, and biodistribution of possible candidates for these photosensitizing drugs. Phthalocyanines (Pcs) are good photosensitizers for this purpose. Here, we describe an approach to the application of photodynamic therapy with metal-phthalocyanines [zinc-phthalocyanine (ZnPc) and cobalt-phthalocyanine (CoPc)] and their carboxylic acid derivatives in U87-MG cell lines. For the phototoxicity study, percent viability values were calculated using the MTT test. The results showed that cell death was effectively induced in U87-MG cells. In our study, the phthalocyanines applied in the in vitro treatment of glioblastoma cell lines with PDT have shown high toxicity and the treatment has been successful. Our findings highlight the potential of ZnPc-COOH and CoPc-COOH with their carboxylic acid derivatives as biological material for biomedical applications in the treatment of glioblastoma cells.

多形性胶质母细胞瘤 (GBM) 是一种侵袭性致命性脑肿瘤，往往发生在老年人中，有多种亚型。胶质母细胞瘤的发生和进展机制尚不清楚，这一事实是该疾病治疗的障碍。为此，近年来进行了研究以开发新的治疗方法。光动力疗法（PDT）是一种已获得批准的治疗方法，并且在大多数临床试验中被认为是安全的。在光敏剂（PS）的帮助下，促进肿瘤生长消退，旨在延长神经胶质瘤进展患者的生存期。开展针对这些光敏药物的可能候选药物的开发、应用和生物分布的研究极其重要。酞菁 (Pcs) 是用于此目的的良好光敏剂。在这里，我们描述了一种在 U87-MG 细胞系中应用金属酞菁 [锌酞菁 (ZnPc) 和钴酞菁 (CoPc)] 及其羧酸衍生物进行光动力疗法的方法。对于光毒性研究，使用 MTT 测试计算百分比活力值。结果表明，U87-MG细胞中细胞死亡被有效诱导。在我们的研究中，酞菁应用于 结果表明，U87-MG细胞中细胞死亡被有效诱导。在我们的研究中，酞菁应用于 结果表明，U87-MG细胞中细胞死亡被有效诱导。在我们的研究中，酞菁应用于PDT 对胶质母细胞瘤细胞系的体外治疗显示出高毒性，并且治疗取得了成功。我们的研究结果强调了 ZnPc-COOH 和 CoPc-COOH 及其羧酸衍生物作为生物材料在治疗胶质母细胞瘤细胞的生物医学应用中的潜力。