Abstract

Objective

To identify key research gaps regarding medication therapy to prevent osteoporotic fractures in men.

Data sources

Articles from the peer-reviewed literature containing empirical studies of the use of medication therapy for fracture prevention in men, either in clinical trials or observational studies.

Study selection and data extraction

We searched PubMed with search terms including “osteoporosis AND medication therapy management”. We read all articles to ensure that they were indeed empirical studies of our topic. For each included study, we searched for all articles in the bibliography, all articles that cited the article, and all related articles, using these functions in PubMed.

Data synthesis

We have identified six research gaps that could inform the more rational, evidence-based treatment of male osteoporosis. Specifically, among men, we lack key information about: (1) whether treatment can prevent clinical fractures, (2) rates of side effects and complications of therapy, (3) the role of testosterone in treatment, (4) the comparative effectiveness of different therapeutic regimens, (5) role of drug holidays for those receiving bisphosphonates and sequential therapies, and (6) effectiveness of therapy for secondary prevention.

Relevance to patient care and clinical practice

Addressing these six topics should be key goal for the next decade of research on male osteoporosis.

中文翻译：

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男性骨质疏松症治疗的证据差距：研究议程

摘要

客观的

确定预防男性骨质疏松性骨折药物治疗的关键研究空白。

数据源

同行评审文献中的文章包含在临床试验或观察性研究中使用药物治疗预防男性骨折的实证研究。

研究选择和数据提取

我们用包括“骨质疏松症和药物治疗管理”在内的搜索词搜索了 PubMed。我们阅读了所有文章，以确保它们确实是我们主题的实证研究。对于每项纳入的研究，我们使用 PubMed 中的这些功能搜索了参考书目中的所有文章、引用该文章的所有文章以及所有相关文章。

数据综合

我们发现了六个研究空白，可以为男性骨质疏松症的更合理、循证治疗提供信息。具体来说，在男性中，我们缺乏以下关键信息：(1) 治疗是否可以预防临床骨折，(2) 治疗的副作用和并发症发生率，(3) 睾酮在治疗中的作用，(4) 治疗的相对有效性不同的治疗方案，(5) 药物假期对于接受双膦酸盐和序贯治疗的患者的作用，以及 (6) 二级预防治疗的有效性。

与患者护理和临床实践的相关性

解决这六个主题应该是未来十年男性骨质疏松症研究的关键目标。