This follow-up study assessed the impact of a nitrate-rich diet on salivary nitrate/nitrite levels and the recovery of therapy-induced vascular impairments in a cohort of 39 periodontitis patients treated by standard subgingival mechanical plaque removal (PMPR). At baseline, saliva samples for nitrate/nitrite analysis were collected, and peripheral/central blood and augmentation pressure was documented using the Arteriograph^® recording system. Immediately after, PMPR vascular parameters were reassessed. All study patients received a randomly allocated supply of a lettuce beverage to be consumed for 14 days, containing either a daily dosage of 200 mg nitrate (test group, n = 20) or being void of nitrate (placebo group, n = 19). At day 14, salivary and vascular parameters were reassessed. Initial salivary and vascular parameters did not differ significantly between the groups. PMPR impaired all vascular parameters in both groups with no differences between the groups. At day 14, salivary nitrate/nitrite levels of the test group were significantly elevated compared to baseline. All vascular parameters had significantly recovered from the impairment inflicted by PMPR. In the placebo group, by contrast, salivary parameters did not differ significantly from baseline, and the recovery of impaired vascular parameters was restricted to a significant improvement of diastolic blood pressure. Correlation analysis identified a significant inverse correlation between salivary nitrate/nitrite sum and central/peripheral blood pressure and augmentation pressure. In conclusion, the data of this subanalysis suggest that increasing salivary nitrate/nitrite levels by a diet rich in nitrate may improve recovery of therapy-induced vascular impairments after PMPR.

这项后续研究评估了富含硝酸盐的饮食对唾液硝酸盐/亚硝酸盐水平的影响，以及对 39 名接受标准龈下机械牙菌斑清除 (PMPR) 治疗的牙周炎患者的治疗引起的血管损伤的恢复的影响。^{在基线时，收集用于硝酸盐/亚硝酸盐分析的唾液样本，并使用Arteriograph ®}记录系统记录外周/中心血液和增压压力。之后立即重新评估 PMPR 血管参数。所有研究患者均接受随机分配的生菜饮料，饮用 14 天，每日剂量为 200 毫克硝酸盐（测试组，n = 20）或不含硝酸盐（安慰剂组，n = 19）。第14天，重新评估唾液和血管参数。各组之间的初始唾液和血管参数没有显着差异。PMPR 损害了两组的所有血管参数，且组间没有差异。第 14 天，测试组的唾液硝酸盐/亚硝酸盐水平与基线相比显着升高。所有血管参数均已从 PMPR 造成的损伤中显着恢复。相比之下，在安慰剂组中，唾液参数与基线没有显着差异，受损血管参数的恢复仅限于舒张压的显着改善。相关分析发现唾液硝酸盐/亚硝酸盐总量与中心/外周血压和增压压之间存在显着的负相关。总之，该子分析的数据表明，通过富含硝酸盐的饮食来增加唾液硝酸盐/亚硝酸盐水平可能会改善 PMPR 后治疗引起的血管损伤的恢复。