In responding to the calls for revisiting the role that hippocampus (HIP) plays in semantic memory retrieval, this study used functional neuroimaging-based connectivity technique to elucidate the functional brain network involved in retrieving the correct and incorrect science-related semantic memories. Unlike episodic memory retrieval, the 40 scientific concepts learned during middle and high school were selected to assess 46 science majors’ semantic memory retrieval and correctness monitoring, which requires neither the support of spatial information nor events to retrieve the memory. Our results demonstrated that HIP was significantly and robustly engaged in the semantic memory retrieval of correct scientific concepts than incorrect ones. Importantly, the Granger causality analysis indicated that effective connectivity of $\mathrm{\text{INS}}\to \mathrm{\text{HIP}}$ and $\mathrm{\text{MTG}}\to \mathrm{\text{HIP}}$ was shared by the semantic memory retrieval of both correct and incorrect scientific concepts. On the other hand, the strengths of connectivity in the $\mathrm{\text{MTG}}\to \mathrm{\text{HIP}}$ and $\mathrm{\text{INS}}\to \mathrm{\text{ACC}}\to \mathrm{\text{HIP}}$ brain networks appeared more pronounced during the processing of correct scientific concepts than of incorrect ones. The shared hippocampal networks highlight the role of the HIP as a hub to coordinate the INS, ACC, and MTG, in turn, support the semantic memory retrieval of scientific concepts.

为了响应重新审视海马体（HIP）在语义记忆检索中的作用的呼声，本研究使用基于功能神经成像的连接技术来阐明参与检索正确和不正确的科学相关语义记忆的功能性大脑网络。与情景记忆检索不同，选取初高中时学到的40个科学概念来评估46名理科专业学生的语义记忆检索和正确性监控，这种检索既不需要空间信息也不需要事件的支持。我们的结果表明，与不正确的科学概念相比，HIP 显着而有力地参与了正确科学概念的语义记忆检索。重要的是，格兰杰因果关系分析表明，$\mathrm{\text{惯性导航系统}}\to \mathrm{\text{时髦的}}$和$\mathrm{\text{MTG}}\to \mathrm{\text{时髦的}}$正确和不正确的科学概念的语义记忆检索共享这一点。另一方面，互联互通的优势$\mathrm{\text{MTG}}\to \mathrm{\text{时髦的}}$和$\mathrm{\text{惯性导航系统}}\to \mathrm{\text{ACC}}\to \mathrm{\text{时髦的}}$在处理正确的科学概念时，大脑网络比处理错误的科学概念时显得更加明显。共享的海马网络强调了 HIP 作为协调 INS、ACC 和 MTG 的枢纽的作用，进而支持科学概念的语义记忆检索。