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Pd(II)dipyrrinato complexes: Synthesis, crystal structure and their antibacterial applications
Journal of Porphyrins and Phthalocyanines ( IF 1.5 ) Pub Date : 2023-06-15 , DOI: 10.1142/s108842462350089x
Neha Manav 1, 2 , Jaydeepsinh Chavda 1 , Saqib Kidwai 3 , Ramandeep Singh 3 , Shigeki Mori 4 , Iti Gupta 1
Affiliation  

The synthesis and biological studies of a series of Pd(II)dipyrrinato complexes are reported. The thiogalactosyl and/or oligoethyleneglycol moieties were linked with themeso-aryl rings of the Pd(II)dipyrrinato complexes. The Pd(II)dipyrrinato complexes were characterized by MASS, IR, UV-Vis, and NMR spectroscopic techniques. Single crystal X-ray structure of the homoleptic Pd(II)dipyrrinato complex (Pd1) revealed typical square planar geometry around the metal center. The anti-bacterial studies of Pd(II) dipyrrinato complexes were performed on theM. Tuberculosis H37Rv and M. Bovis BCG strains and complex Pd4 showed excellent anti-TB activity with MIC values of 25 μM and 12.5 μM, respectively. The ease of synthesis and good MIC values of Pd(II)dipyrrinato complexes make them promising candidates for anti-TB activity.



中文翻译:

Pd(II)二吡啶配合物:合成、晶体结构及其抗菌应用

报道了一系列二吡啶钯配合物的合成和生物学研究。硫代半乳糖基和/或低聚乙二醇部分与Pd(II)二吡啶配合物的消旋芳基环连接。Pd(II)二吡啶配合物通过质谱、红外、紫外-可见和核磁共振光谱技术进行了表征。同配型 Pd(II)二吡啶配合物 ( Pd1 ) 的单晶 X 射线结构揭示了金属中心周围典型的方形平面几何形状。Pd(II) 二吡啶配合物对结核分枝杆菌H37Rv 和牛分枝杆菌 BCG菌株进行了抗菌研究,复合物Pd4 显示出优异的抗结核活性,MIC 值为 25μ米和12.5μ分别为M。Pd(II)二吡啶配合物易于合成且具有良好的 MIC 值,使其成为抗结核活性的有希望的候选者。

更新日期:2023-06-15
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