Glioblastoma multiforme (GBM) is one of the most aggressive brain and spinal cord tumors. Despite the significant development in application of antitumor drugs, no significant increases have been observed in the survival rates of patients with GBM, as GBM cells acquire resistance to conventional anticancer therapeutic agents. Multiple studies have revealed that PI3K/Akt, MAPK, Nanog, STAT 3, and Wnt signaling pathways are involved in GBM progression and invasion. Besides, biological processes such as anti-apoptosis, autophagy, angiogenesis, and stemness promote GBM malignancy. Resveratrol (RESV) is a non-flavonoid polyphenol with high antitumor activity, the potential of which, regulating signaling pathways involved in cancer malignancy, have been demonstrated by many studies. Herein, we present the potential of RESV in both single and combination therapy- targeting various signaling pathways- which induce apoptotic cell death, re-sensitize cancer cells to radiotherapy, and induce chemo-sensitizing effects to eventually inhibit GBM progression.

多形性胶质母细胞瘤（GBM）是最具侵袭性的脑和脊髓肿瘤之一。尽管抗肿瘤药物的应用取得了显着进展，但由于 GBM 细胞对传统抗癌治疗药物产生了耐药性，因此并未观察到 GBM 患者的生存率显着提高。多项研究表明 PI3K/Akt、 MAPK 、Nanog 、STAT 3 和 Wnt 信号通路参与 GBM 进展和侵袭。此外，抗凋亡、自噬、血管生成和干性等生物学过程也会促进GBM恶性。白藜芦醇(RESV) 是一种具有高抗肿瘤活性的非黄酮类多酚，许多研究已证明其调节癌症恶性肿瘤相关信号通路的潜力。在此，我们展示了 RESV 在单一和联合治疗中的潜力 - 针对各种信号通路 - 诱导细胞凋亡，使癌细胞对放疗重新敏感，并诱导化疗增敏作用，最终抑制 GBM 进展。