Hide and skin are complex tissue where the most abundant component is collagen. Matrix metalloproteinases and bacterial collagenases are two kinds of collagenases that can cleave the triple-helical domain of native fibrillar collagens. In this paper, the family members and domain composition of matrix metalloproteinases and bacterial collagenases are summarized. The catalytic mechanism of collagen hydrolysis by collagenases is described, and the methods adopted to date for investigating and regulating collagenases and their inhibitors are reviewed. Furthermore, the applications of collagenases and their inhibitors in biomedicine, food processing and the enzymatic unhairing process in the leather-making industry are presented.

中文翻译：

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胶原酶及其抑制剂：综述

生皮和皮肤是复杂的组织，其中最丰富的成分是胶原蛋白。基质金属蛋白酶和细菌胶原酶是两种可以切割天然纤维状胶原的三螺旋结构域的胶原酶。在本文中，总结了基质金属蛋白酶和细菌胶原酶的家族成员和结构域组成。描述了胶原酶水解胶原蛋白的催化机制，并回顾了迄今为止用于研究和调节胶原酶及其抑制剂的方法。此外，还介绍了胶原酶及其抑制剂在生物医学、食品加工和制革行业酶法脱毛过程中的应用。