INTRODUCTION The early diagnosis of breast carcinoma is of paramount importance in its management. Fine-needle aspiration cytology (FNAC) has the potential to play a pivotal role in providing the relevant information on the aggressiveness of this tumor. But there is no gold standard when it comes to cytological grading of breast carcinoma as there is no consensus between the pathologists and also the clinicians as to which grading is as par with the gold standard Elston-Ellis modification of Scarff-Bloom-Richardson (SBR) histological grading. This study was undertaken to study seven cytological 3-tier grading systems, namely, Robinson's, Fisher's, Mouriquand's, Dabbs', Khan's, Taniguchi's, and Howells's and to correlate them with the Elston-Ellis modification of SBR histological grading system so as to determine the finest cytological grading system which could be reliably used in our routine practice. MATERIAL AND METHODS A total of 117 breast carcinoma cases diagnosed on FNAC were graded using seven 3-tier cytological grading systems and were correlated with Elston-Ellis modification of SBR histological grading system. Concordance, kappa measurement, and various correlation studies were done using SPSS software version 2021. RESULTS Robinson's method showed a better concordance (84.61%), a better correlation (Spearman = 0.750, τ = 0.731, p < 0.001), and a substantial kappa value of agreement (κ = 0.701) with SBR grading system compared to other system closely followed by Fisher's system. CONCLUSIONS Even though all the seven 3-tier cytological grading systems positively correlated with the SBR histologic grading of breast carcinoma, Robinson's method showed better concordance and correlation with a substantial kappa value of agreement in comparison to other 3-tier cytology grading systems. Hence, Robinson's grading which is simpler and also feasible should be incorporated in the routine cytology reporting of breast carcinoma.

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乳腺癌的七个细胞学 3 级分级系统与标准组织学分级的相关评估：一项为期 4 年和 1/2 年的研究。

引言 乳腺癌的早期诊断对其治疗至关重要。细针抽吸细胞学（FNAC）有可能在提供有关该肿瘤侵袭性的相关信息方面发挥关键作用。但乳腺癌的细胞学分级并没有黄金标准，因为病理学家和临床医生对于哪种分级与 Scarff-Bloom-Richardson 的 Elston-Ellis 修正金标准 (SBR) 没有达成共识。 ) 组织学分级。本研究旨在研究七个细胞学三级分级系统，即 Robinson's、Fisher's、Mouriquand's、Dabbs'、Khan's、Taniguchi's 和 Howells's，并将它们与 SBR 组织学分级系统的 Elston-Ellis 修改相关联，以确定最好的细胞学分级系统，可以在我们的日常实践中可靠地使用。材料和方法 总共 117 例经 FNAC 诊断的乳腺癌病例使用 7 个 3 级细胞学分级系统进行分级，并与 SBR 组织学分级系统的 Elston-Ellis 修正版相关。使用 SPSS 软件 2021 版完成一致性、kappa 测量和各种相关性研究。结果 Robinson 方法显示出更好的一致性 (84.61%)、更好的相关性 (Spearman = 0.750, τ = 0.731, p < 0.001) 和显着的 kappa与紧随 Fisher 系统的其他系统相比，SBR 分级系统的一致性值 (κ = 0.701)。结论 尽管所有七个三级细胞学分级系统与乳腺癌的 SBR 组织学分级呈正相关，但与其他三级细胞学分级系统相比，Robinson 方法显示出更好的一致性和相关性，具有显着的一致性 kappa 值。因此，更简单、可行的Robinson分级应纳入乳腺癌的常规细胞学报告中。