Steroidogenic acute regulatory protein (StAR) plays a critical role in the regulation of progesterone (P4) production. Resveratrol (RSV), a natural polyphenol, has beneficial effects on reproductive function. However, its effects on StAR expression and P4 production in human granulosa cells remain undetermined. In this study, we showed that treatment of RSV upregulated StAR expression in human granulosa cells. G protein-coupled estrogen receptor (GPER) and ERK1/2 signaling were involved in RSV-stimulated StAR expression and P4 production. In addition, the expression of a transcriptional repressor, Snail, was downregulated by RSV, which contributed to the RSV-induced inductions of StAR expression and P4 production.

中文翻译：

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白藜芦醇通过 GPER 介导的人颗粒细胞中 Snail 表达的下调来刺激 StAR 表达和黄体酮产生。

类固醇生成急性调节蛋白 (StAR) 在黄体酮 (P4) 产生的调节中发挥着关键作用。白藜芦醇 (RSV) 是一种天然多酚，对生殖功能具有有益作用。然而，其对人颗粒细胞中 StAR 表达和 P4 产生的影响仍未确定。在这项研究中，我们发现 RSV 治疗上调了人颗粒细胞中 StAR 的表达。G 蛋白偶联雌激素受体 (GPER) 和 ERK1/2 信号传导参与 RSV 刺激的 StAR 表达和 P4 产生。此外，RSV 下调了转录抑制因子 Snail 的表达，这有助于 RSV 诱导 StAR 表达和 P4 产生。