Abstract

The characterization of callosal white matter is crucial for understanding the relationship between brain structure and bimanual motor function. An earlier literature review established this. With advancements in neuroimaging and data modeling, we aim to provide an update on the existing literature. Firstly, we highlight new CC parcellation approaches, such as functional MRI- and atlas-informed tractography and in vivo histology. Secondly, we elaborate on recent insights into the CC’s role in bimanual coordination, drawing evidence from studies on healthy young and older adults, patients and training-related callosal plasticity. We also reflect on progress in the field and propose future perspectives to inspire research on the underlying mechanisms of structural-functional interactions.

摘要

胼胝体白质的表征对于理解大脑结构和双手运动功能之间的关系至关重要。早期的文献综述证实了这一点。随着神经影像学和数据建模的进步，我们的目标是提供现有文献的更新。首先，我们重点介绍新的 CC 分割方法，例如功能性 MRI 和图谱信息纤维束成像以及体内组织学。其次，我们从对健康年轻人和老年人、患者以及与训练相关的胼胝体可塑性的研究中汲取证据，详细阐述了对 CC 在双手协调中的作用的最新见解。我们还反思了该领域的进展并提出了未来的观点，以激发对结构-功能相互作用的潜在机制的研究。