Abstract

One of the main issues in modern medicine is the decrease in the efficacy of antibiotic therapy against resistant microorganisms. The advent of antimicrobial resistance has added significantly to the impact of infectious diseases, in number of infections, as well as added healthcare costs. The development of antibiotic tolerance and resistance is influenced by a variety of environmental variables, and it is important to identify these environmental factors as part of any strategy for combating antibiotic resistance. The review aims to emphasize that biogenic polyamines are one of such environmental cues that impacts the antibiotic resistance in bacteria. The biogenic polyamines can help bacteria acquire resistance to antibiotics either by regulating the level of number of porin channels in the outer membrane, by modifying the outer membrane liposaccharides or by protecting macromolecule from antibiotic stress. Thus, understanding the way polyamines function in bacteria can thus be beneficial while designing the drugs to combat diseases.

摘要

现代医学的主要问题之一是抗生素治疗对耐药微生物的功效下降。抗菌素耐药性的出现大大增加了传染病的影响、感染数量以及医疗费用。抗生素耐受性和耐药性的发展受到多种环境变量的影响，识别这些环境因素作为对抗抗生素耐药性策略的一部分非常重要。该综述旨在强调生物多胺是影响细菌抗生素耐药性的环境因素之一。生物多胺可以通过调节外膜孔蛋白通道数量的水平来帮助细菌获得对抗生素的耐药性，通过修饰外膜脂糖或保护大分子免受抗生素应激。因此，了解多胺在细菌中的作用方式对于设计对抗疾病的药物是有益的。