In recent times mucoadhesive drug delivery systems are gaining popularity in oral cancer. It is a malignancy with high global prevalence. Despite significant advances in cancer therapeutics, improving the prognosis of late-stage oral cancer remains challenging. Targeted therapy using mucoadhesive polymers can improve oral cancer patients' overall outcome by offering enhanced oral mucosa bioavailability, better drug distribution and tissue targeting, and minimizing systemic side effects. Mucoadhesive polymers can also be delivered via different formulations such as tablets, films, patches, gels, and nanoparticles. These polymers can deliver an array of medicines, making them an adaptable drug delivery approach. Drug delivery techniques based on these mucoadhesive polymers are gaining traction and have immense potential as a prospective treatment for late-stage oral cancer. This review examines leading research in mucoadhesive polymers and discusses their potential applications in treating oral cancer.

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超越传统疗法：粘膜粘附聚合物作为口腔癌治疗的新领域

近年来，粘膜粘附药物递送系统在口腔癌中越来越受欢迎。它是一种全球患病率较高的恶性肿瘤。尽管癌症治疗取得了重大进展，但改善晚期口腔癌的预后仍然具有挑战性。使用粘膜粘附聚合物的靶向治疗可以通过增强口腔粘膜生物利用度、更好的药物分布和组织靶向性以及最大限度地减少全身副作用来改善口腔癌患者的总体预后。粘膜粘附聚合物还可以通过不同的制剂来递送，例如片剂、薄膜、贴剂、凝胶和纳米颗粒。这些聚合物可以输送多种药物，使其成为一种适应性强的药物输送方法。基于这些粘膜粘附聚合物的药物输送技术正在获得关注，并且作为晚期口腔癌的前瞻性治疗具有巨大的潜力。这篇综述考察了粘膜粘附聚合物的领先研究，并讨论了它们在治疗口腔癌中的潜在应用。