ABSTRACT

There is conflicting evidence whether single-suture craniosynostosis (SSC), is linked to adversities of cognitive development. To assess the evidence for a link between SSC and cognition, a systematic literature search was conducted and eligible studies assessed for inclusion by two independent readers. Forty-eight studies met inclusion criteria. Small to medium but persistent effects on both general and some specific cognitive functions across age bands were found in higher quality studies for SSC overall. There was limited evidence for effects related to surgical correction. Methodologies varied substantially and there was a lack of longitudinal studies using broad assessment batteries.

摘要

单缝颅缝早闭（SSC）是否与认知发展逆境有关，目前存在相互矛盾的证据。为了评估 SSC 和认知之间联系的证据，我们进行了系统的文献检索，并由两名独立读者评估了合格的研究是否纳入。四十八项研究符合纳入标准。在总体 SSC 的更高质量研究中发现，对跨年龄段的一般和某些特定认知功能有小到中等但持续的影响。与手术矫正相关的影响的证据有限。方法差异很大，并且缺乏使用广泛评估组合的纵向研究。