Ionic liquids (IL) have attained immense interest as substitutes for conventionally available surfactants because of their exceptionally favorable physicochemical properties. Most synthesized IL surfactants are not environmentally benign, and even utilizing high concentration, they form unstable micelles. In this regard, we have synthesized biocompatible and halogen free choline based ionic liquids by varying anions (choline oleate and cholinium bis(2-ethylhexyl) sulfosuccinate) and further investigated their micellization behavior in presence of the drug Cetrizine dihydrochloride. Characterizations of these synthesized ionic liquids were performed utilizing 1HNMR spectroscopy. The thermodynamic investigation and determination of various surface-active parameters were based on tensiometry and conductometric titrations. The CMC value of choline oleate ([CHO][Ole]) was found to be lower than that of [Cho][AOT] and thus it has a better surface activity. The thermodynamic parameters ( Δ G m 0 ${{\Delta}G}_{m}^{0}$ , Δ H m 0 ${{\Delta}H}_{m}^{0}$ , and Δ S m 0 ${{\Delta}S}_{m}^{0}$ ) signifies spontaneous, stable, exothermic and entropy driven nature of micellization process. The various interfacial and surface parameters have been evaluated employing tensiometry. These environmentally friendly ionic liquids have been utilized as substitute for conventional surfactants including their applications in biology and pharmaceutical industries.

中文翻译：

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药物二盐酸西替利嗪存在下胆碱基离子液体的热力学和胶束化行为

离子液体 (IL) 作为传统表面活性剂的替代品因其极其有利的物理化学性质而引起了极大的兴趣。大多数合成的离子液体表面活性剂对环境不利，即使使用高浓度，它们也会形成不稳定的胶束。在这方面，我们通过改变阴离子（油酸胆碱和双（2-乙基己基）磺基琥珀酸胆碱）合成了生物相容性且无卤素的胆碱基离子液体，并进一步研究了它们在药物二盐酸西替利嗪存在下的胶束化行为。这些合成的离子液体的表征是利用1核磁共振氢谱。热力学研究和各种表面活性参数的测定是基于张力滴定法和电导滴定法。研究发现油酸胆碱（[CHO][Ole]）的CMC值低于[Cho][AOT]，因此具有更好的表面活性。热力学参数（ Δ G 米 0 ${{\Delta}G}_{m}^{0}$ , Δ H 米 0 ${{\Delta}H}_{m}^{0}$ ， 和 Δ S 米 0 ${{\Delta}S}_{m}^{0}$ )表示胶束化过程的自发、稳定、放热和熵驱动的性质。各种界面和表面参数已采用张力测定法进行了评估。这些环境友好的离子液体已被用作传统表面活性剂的替代品，包括它们在生物和制药工业中的应用。