Stroke patients are often left with permanent disabilities with no regenerative treatment options. Unbiased RNA sequencing studies decoding the transcriptional signature of stroked tissue hold promise to identify new potential targets and pathways directed to improve treatment for stroke patients. Here, gene expression profiles of stroked tissue across different time points, species, and stroke models were compared using NCBI GEO database. In total, 34 datasets from mice, rats, humans, and primates were included, exploring gene expression differences in healthy and stroked brain tissue. Distinct changes in gene expression and pathway enrichment revealed the heterogenicity of the stroke pathology in stroke-related pathways e.g., inflammatory responses, vascular repair, remodelling and cell proliferation and adhesion but also in diverse general, stroke-unrelated pathways that have to be carefully considered when evaluating new promising therapeutic targets.

中文翻译：

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跨物种缺血性中风相关基因表达谱：荟萃分析

中风患者通常会留下永久性残疾，并且没有再生治疗选择。无偏见的 RNA 测序研究解码中风组织的转录特征，有望确定新的潜在靶点和途径，从而改善中风患者的治疗。在这里，使用 NCBI GEO 数据库比较了不同时间点、物种和中风模型的中风组织的基因表达谱。总共包括来自小鼠、大鼠、人类和灵长类动物的 34 个数据集，探索健康和中风脑组织中的基因表达差异。基因表达和通路富集的明显变化揭示了中风病理学在中风相关通路中的异质性，例如炎症反应、血管修复、重塑以及细胞增殖和粘附，而且在不同的一般情况下，