Deep brain stimulation (DBS) is a widely used clinical therapy that modulates neuronal firing in subcortical structures, eliciting downstream network effects. Its effectiveness is determined by electrode geometry and location as well as adjustable stimulation parameters including pulse width, interstimulus interval, frequency, and amplitude. These parameters are often determined empirically during clinical or intraoperative programming and can be altered to an almost unlimited number of combinations. Conventional high-frequency stimulation uses a continuous high-frequency square-wave pulse (typically 130–160 Hz), but other stimulation patterns may prove efficacious, such as continuous or bursting theta-frequencies, variable frequencies, and coordinated reset stimulation. Here we summarize the current landscape and potential clinical applications for novel stimulation patterns.

中文翻译：

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神经系统和神经精神疾病的深部脑刺激的替代模式

深部脑刺激 (DBS) 是一种广泛使用的临床疗法，可调节皮质下结构中的神经元放电，引发下游网络效应。其有效性取决于电极的几何形状和位置以及可调节的刺激参数，包括脉冲宽度、刺激间隔、频率和幅度。这些参数通常是在临床或术中编程期间凭经验确定的，并且可以更改为几乎无限数量的组合。传统的高频刺激使用连续的高频方波脉冲（通常为 130-160 Hz），但其他刺激模式可能被证明是有效的，例如连续或突发 theta 频率、可变频率和协调重置刺激。