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The trend of allogeneic tendon decellularization: literature review
Cell and Tissue Banking ( IF 1.5 ) Pub Date : 2023-06-24 , DOI: 10.1007/s10561-023-10097-x
Yangyang Jin 1 , Qi Sun 1 , Rongxing Ma 1 , Ruifeng Li 1 , Ruiqi Qiao 1 , Jikai Li 1 , Limin Wang 2 , Yongcheng Hu 3
Affiliation  

Tendon injuries repair is a significant burden for orthopaedic surgeons. Finding a proper graft material to repair tendon is one of the main challenges in orthopaedics, for which the requirement of substitute for tendon repair would be different for each clinical application. Among biological scaffolds, the use of decellularized tendon increasingly represents an interesting approach to treat tendon injuries and several articles have investigated the approaches of tendon decellularization. To understand the outcomes of the the approaches of tendon decellularization on effect of tendon transplantation, a literature review was performed. This review was conducted by searching in Pubmed and Embase and 64 studies were included in this study. The findings revealed that the common approaches to decellularize tendon include chemical, physical, and enzymatic decellularization methods or their combination. With the development of tissue engineering, researchers also put forward new theories such as automatic acellular machine, 3D printing technology to manufacture acellular scaffold.



中文翻译:

同种异体肌腱脱细胞化趋势:文献综述

肌腱损伤修复对于骨科医生来说是一个重大负担。寻找合适的移植材料来修复肌腱是骨科的主要挑战之一,每种临床应用对肌腱修复替代品的要求都不同。在生物支架中,脱细胞肌腱的使用越来越成为治疗肌腱损伤的一种有趣的方法,并且有几篇文章研究了肌腱脱细胞化的方法。为了了解肌腱脱细胞方法对肌腱移植效果的影响,进行了文献综述。本综述是通过 Pubmed 和 Embase 检索进行的,本研究纳入了 64 项研究。研究结果表明,常见的肌腱脱细胞方法包括化学法、物理法、和酶促脱细胞方法或其组合。随着组织工程的发展,研究人员也提出了自动脱细胞机、3D打印技术等新理论来制造脱细胞支架。

更新日期:2023-06-25
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