We herein report a case of Behçet's disease in a 27-year-old female who suffered from generalized skin rashes for one week. After hospitalization, massive bloody stools accompanying hypovolemic shock occurred. Emergency abdominal computed tomography-angiography failed to detect the bleeding source. Esophagogastroduodenoscopy also demonstrated no definite bleeding points. Ileocolonoscopy showed multiple large and deep ulcers with some blood coating and mild oozing in the terminal ileum. We initially performed epinephrine injection and hemoclips for her intestinal bleeding. However, massive bloody stools still continued. Thus, we prescribed a loading dose of 160 mg adalimumab followed by weekly 80 mg adalimumab subcutaneous injections to the patient. Following this treatment, her gastrointestinal bleeding gradually subsided and completely stopped within a few days. After three-week therapy with adalimumab, capsule endoscopy showed several healing ulcers without bleeding in the distal to the terminal ileum. She continues to be treated with adalimumab, azathioprine, and mesalazine without recurrent bleeding.

中文翻译：

---

阿达木单抗成功治疗了白塞氏病引起的大量小肠出血。

我们在此报告一例白塞病病例，患者为一名 27 岁女性，全身出现皮疹一周。住院后出现大量血便并伴有低血容量性休克。紧急腹部计算机断层扫描-血管造影未能查出出血源。食管胃十二指肠镜检查也未发现明确的出血点。回肠结肠镜检查显示回肠末端有多个大而深的溃疡，有一些血液涂层和轻度渗出。我们最初为她进行了肾上腺素注射和止血夹治疗肠道出血。然而，大量血便仍在继续。因此，我们给患者开了 160 mg 阿达木单抗的负荷剂量，然后每周皮下注射 80 mg 阿达木单抗。经过这次治疗，她的消化道出血逐渐减少，并在几天内完全停止。阿达木单抗治疗三周后，胶囊内窥镜检查显示回肠末端有数个正在愈合的溃疡，无出血。她继续接受阿达木单抗、硫唑嘌呤和美沙拉嗪治疗，没有出现复发性出血。