Perfluorooctane sulfonate (PFOS) is a man-made fluorinated compound employed in a variety of industrial and civilian applications. Due to its long elimination half-life and promotion of oxidative stress and inflammation, it is one of the most abundant organic contaminants. The present study was designed to determine the cytotoxic effect of PFOS on adult male rat cardiac tissue and to assess the cardioprotective role of the flavonoid quercetin (Que), which possesses antioxidant, anti-inflammatory, and anti-apoptotic properties. Twenty-four adult male Sprague–Dawley rats were randomly divided into four equal groups: Group I (Control). Group II (Que) received Que (75 mg/kg/day for 4 weeks) by oral gavage. Group III (PFOS group): supplemented orally with PFOS (20 mg/kg/day for 4 weeks) and Group IV (PF OS/Que). The rat heart was processed for histological, immunohistochemical, and gene expression studies. The PFOS group showed histological alterations in the myocardium that were partially reversed by the administration of Que. The inflammatory biomarkers (TNF, IL-6, and IL-1), lipid profile, TSH, MDA, and serum cardiac enzymes (LDH and CK-MB) were all altered. These findings collectively suggest that PFOS had adverse effects on the cardiac muscle structure, and these effects were alleviated by quercetin, which is a promising cardioprotective flavonoid.

全氟辛烷磺酸 (PFOS) 是一种人造氟化化合物，用于各种工业和民用应用。由于其消除半衰期长并促进氧化应激和炎症，它是最丰富的有机污染物之一。本研究旨在确定 PFOS 对成年雄性大鼠心脏组织的细胞毒性作用，并评估类黄酮槲皮素 (Que) 的心脏保护作用，槲皮素具有抗氧化、抗炎和抗凋亡特性。将 24 只成年雄性 Sprague-Dawley 大鼠随机分为四个相等的组：I 组（对照组）。第二组（Que）通过口服强饲法接受 Que（75 mg/kg/天，持续 4 周）。III 组（PFOS 组）：口服补充 PFOS（20 mg/kg/天，持续 4 周）和 IV 组（PF OS/Que）。处理大鼠心脏用于组织学、免疫组织化学和基因表达研究。PFOS 组显示心肌组织学改变，但服用 Que 后部分逆转。炎症生物标志物（TNF、IL-6 和 IL-1）、血脂、TSH、MDA 和血清心肌酶（LDH 和 CK-MB）均发生改变。这些发现共同表明，全氟辛烷磺酸对心肌结构有不利影响，而槲皮素可以减轻这些影响，槲皮素是一种有前途的心脏保护类黄酮。