Oxygen pressure plays an integral role in regulating various aspects of cellular biology. Cell metabolism, proliferation, morphology, senescence, metastasis, and angiogenesis are some instances that are affected by different tensions of oxygen. Hyperoxia or high oxygen concentration, enforces the production of reactive oxygen species (ROS) that disturbs physiological homeostasis, and consequently, in the absence of antioxidants, cells and tissues are directed to an undesired fate. On the other side, hypoxia or low oxygen concentration, impacts cell metabolism and fate strongly through inducing changes in the expression level of specific genes. Thus, understanding the precise mechanism and the extent of the implication of oxygen tension and ROS in biological events is crucial to maintaining the desired cell and tissue function for application in regenerative medicine strategies. Herein, a comprehensive literature review has been performed to find out the impacts of oxygen tensions on the various behaviors of cells or tissues.

氧压在调节细胞生物学的各个方面起着不可或缺的作用。细胞代谢、增殖、形态、衰老、转移和血管生成是受不同氧张力影响的一些例子。高氧或高氧浓度会促进活性氧 (ROS) 的产生，从而扰乱生理稳态，因此，在缺乏抗氧化剂的情况下，细胞和组织会走向不良的命运。另一方面，缺氧或低氧浓度通过诱导特定基因表达水平的变化，强烈影响细胞代谢和命运。因此，了解氧张力和活性氧在生物事件中的影响的精确机制和程度对于维持再生医学策略中所需的细胞和组织功能至关重要。在此，进行了全面的文献综述，以找出氧张力对细胞或组织各种行为的影响。