B cell receptor (BCR)-mediated antigen-specific recognition activates B lymphocytes and drives the humoral immune response. This enables the generation of antibody-producing plasma cells, the effector arm of the B cell immune response, and of memory B cells, which confer protection against additional encounters with antigen. B cells search for cognate antigen in the complex cellular microarchitecture of secondary lymphoid organs, where antigens are captured and exposed on the surface of different immune cells. While scanning the cell network, the BCR can be stimulated by a specific antigen and elicit the establishment of the immune synapse with the antigen-presenting cell. At the immune synapse, an integrin-enriched supramolecular domain is assembled at the periphery of the B cell contact with the antigen-presenting cell, ensuring a stable and long-lasting interaction. The coordinated action of the actomyosin cytoskeleton and the microtubule network in the inner B cell space provides a structural framework that integrates signaling events and antigen uptake through the generation of traction forces and organelle polarization. Accordingly, the B cell immune synapse can be envisioned as a temporal engine that drives the molecular mechanisms needed for successful B cell activation. Here, I review different aspects of the B cell synapse engine and provide insights into other aspects poorly known or virtually unexplored.

B 细胞受体 (BCR) 介导的抗原特异性识别可激活 B 淋巴细胞并驱动体液免疫反应。这使得产生抗体的浆细胞（B 细胞免疫反应的效应臂）和记忆 B 细胞的产生成为可能，从而提供保护，防止与抗原的额外接触。B 细胞在次级淋巴器官复杂的细胞微结构中寻找同源抗原，其中抗原被捕获并暴露在不同免疫细胞的表面上。在扫描细胞网络时，BCR 可以受到特定抗原的刺激，并引发与抗原呈递细胞建立免疫突触。在免疫突触处，富含整合素的超分子结构域在 B 细胞与抗原呈递细胞接触的外围组装，确保稳定且持久的相互作用。肌动球蛋白细胞骨架和内部 B 细胞空间中的微管网络的协调作用提供了一个结构框架，通过产生牵引力和细胞器极化来整合信号事件和抗原摄取。因此，B 细胞免疫突触可以被设想为一个时间引擎，驱动 B 细胞成功激活所需的分子机制。在这里，我回顾了 B 细胞突触引擎的不同方面，并提供了对鲜为人知或几乎未探索的其他方面的见解。