The self-assembly of two lipophilic dinucleoside molecules that have a common structure, comprising a bent “Z-shaped” central block substituted at the edges with complementary G and C nucleobases, are studied in this work by a combination of 1D and 2D NMR experiments, as well as by absorption, fluorescence and circular dichroism measurements as a function of the temperature and the concentration. Watson-Crick pairing affords cyclic tetramer G:C H-bound species that are less stable than those formed by related linear dinucleosides and that, in principle, due to the unusual monomer geometry, can establish an equilibrium between different conformations with the shape of a square and a rhomb.

本工作通过一维和二维核磁共振实验相结合，研究了具有共同结构的两个亲脂性二核苷分子的自组装，其中包括弯曲的“Z 形”中心块，其边缘被互补的 G 和 C 核碱基取代。 ，以及作为温度和浓度函数的吸收、荧光和圆二色性测量。Watson-Crick 配对提供了环状四聚体 G:C H 结合物质，其稳定性低于由相关线性二核苷形成的物质，原则上，由于不寻常的单体几何形状，可以在形状为 a 的不同构象之间建立平衡。正方形和菱形。