Medical devices are becoming more and more significant in our daily life. For implantable medical devices, good biocompatibility is required for further use in vivo. Thus, surface modification of medical devices is really important, which gives a wide application scene for a silane coupling agent. The silane coupling agent is able to form a durable bond between organic and inorganic materials. The dehydration process provides linking sites to achieve condensation of two hydroxyl groups. The forming covalent bond brings excellent mechanical properties among different surfaces. Indeed, the silane coupling agent is a popular component in surface modification. Metals, proteins, and hydrogels are using silane coupling agent to link parts commonly. The mild reaction environment also brings advantages for the spread of the silane coupling agent. In this review, we summarize two main methods of using the silane coupling agent. One is acting as a crosslinker mixed in the whole system, and the other is to provide a bridge between different surfaces. Moreover, we introduce their applications in biomedical devices.

中文翻译：

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生物医用材料中的硅烷偶联剂。

医疗设备在我们的日常生活中变得越来越重要。对于植入式医疗器械来说，需要良好的生物相容性才能在体内进一步使用。因此，医疗器械的表面改性非常重要，这为硅烷偶联剂提供了广阔的应用场景。硅烷偶联剂能够在有机和无机材料之间形成持久的结合。脱水过程提供了连接位点以实现两个羟基的缩合。形成的共价键使不同表面之间具有优异的机械性能。事实上，硅烷偶联剂是表面改性中常用的成分。金属、蛋白质和水凝胶通常使用硅烷偶联剂来连接零件。温和的反应环境也为硅烷偶联剂的推广带来了优势。在这篇综述中，我们总结了使用硅烷偶联剂的两种主要方法。一是作为混合在整个体系中的交联剂，二是在不同表面之间提供桥梁。此外，我们还介绍了它们在生物医学设备中的应用。