Mesenchymal stromal cells (MSCs) have attracted scientific and medical interest due to their self-renewing properties, pluripotency, and paracrine function. However, one of the main limitations to the clinical application of MSCs is their loss of efficacy after transplantation in vivo. Various bioengineering technologies to provide stem cell niche-like conditions have the potential to overcome this limitation. Here, focusing on the stem cell niche microenvironment, studies to maximize the immunomodulatory potential of MSCs by controlling biomechanical stimuli, including shear stress, hydrostatic pressure, stretch, and biophysical cues, such as extracellular matrix mimetic substrates, are discussed. The application of biomechanical forces or biophysical cues to the stem cell microenvironment will be beneficial for enhancing the immunomodulatory function of MSCs during cultivation and overcoming the current limitations of MSC therapy.

中文翻译：

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仿生平台在增强间充质基质细胞免疫调节功能中的应用。

间充质基质细胞（MSC）由于其自我更新特性、多能性和旁分泌功能而引起了科学和医学的兴趣。然而，间充质干细胞临床应用的主要限制之一是其在体内移植后功效丧失。提供干细胞生态位样条件的各种生物工程技术有可能克服这一限制。在此，重点关注干细胞微环境，讨论通过控制生物力学刺激（包括剪切应力、静水压力、拉伸和生物物理线索，例如细胞外基质模拟底物）来最大化 MSC 的免疫调节潜力的研究。将生物力学力或生物物理线索应用于干细胞微环境将有利于增强间充质干细胞在培养过程中的免疫调节功能，并克服目前间充质干细胞治疗的局限性。