Glioblastoma (GBM) is an aggressive primary brain tumor characterized by its heterogeneity and high recurrence and lethality rates. Glioblastoma stem cells (GSCs) play a crucial role in therapy resistance and tumor recurrence. Therefore, targeting GSCs is a key objective in developing effective treatments for GBM. The role of Parathyroid hormone-related peptide (PTHrP) in GBM and its impact on GSCs remains unclear. This study aimed to investigate the effect of PTHrP on GSCs and its potential as a therapeutic target for GBM.

中文翻译：

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甲状旁腺激素相关蛋白通过激活 cAMP/PKA 信号通路促进患者来源的胶质母细胞瘤干细胞的增殖。

胶质母细胞瘤（GBM）是一种侵袭性原发性脑肿瘤，其特点是异质性、高复发率和致死率。胶质母细胞瘤干细胞（GSC）在治疗抵抗和肿瘤复发中发挥着至关重要的作用。因此，靶向 GSC 是开发 GBM 有效治疗方法的关键目标。甲状旁腺激素相关肽 (PTHrP) 在 GBM 中的作用及其对 GSC 的影响仍不清楚。本研究旨在探讨 PTHrP 对 GSC 的影响及其作为 GBM 治疗靶点的潜力。