Interventional procedures (IPs) have been widely used to treat vascular anomalies (VA) in recent years. However, patients are exposed to low-dose X-ray ionizing radiation (IR) during these fluoroscopy-guided IPs. We collected clinical information and IR doses during IPs and measured biomarkers including γ-H2AX, chromosome aberrations (CA), and micronuclei (MN), which underpin radiation-induced DNA damage, from 74 pediatric patients before and after IPs. For the 74 children, the range of dose-area product (DAP) values was from 1.2 to 1754.6 Gy∙cm², with a median value of 27.1 Gy∙cm². DAP values were significantly higher in children with lesions in the head and neck than in the limbs and trunk; the age and weight of children revealed a strong positive correlation with DAP values. The treated patients as a group demonstrated an increase in all three endpoints relative to baseline following IPs. Children with vascular tumors have a higher risk of dicentric chromosome + centric ring (dic+r) and cytokinesis-block micronucleus (CBMN) after IPs than children with vascular malformations. The younger the patient, the greater the risk of CA after IPs. Moreover, rogue cells (RCs) were found in five children (approximately 10%) after IPs, and the rates of dic+r and CBMN were significantly higher than those of other children (Z = −3.576, p < 0.001). These results suggest that there may be some children with VA who are particularly sensitive to IR, but more data and more in-depth experiments will be needed to verify this in the future.

近年来，介入手术（IP）已广泛用于治疗血管异常（VA）。然而，在这些透视引导的 IP 过程中，患者会暴露于低剂量 X 射线电离辐射 (IR)。我们收集了 IP 期间的临床信息和 IR 剂量，并测量了 74 名儿科患者 IP 前后的生物标志物，包括 γ-H2AX、染色体畸变 (CA) 和微核 (MN)，它们是辐射诱导的 DNA 损伤的基础。74名儿童的剂量面积乘积（DAP）值范围为1.2至1754.6 Gy∙cm ²，中值为27.1 Gy∙cm ²。头颈部病变患儿DAP值显着高于四肢、躯干；儿童的年龄和体重与DAP值呈很强的正相关。接受治疗的患者作为一个整体，在 IP 治疗后，所有三个终点相对于基线均有所增加。血管瘤儿童IPs后出现双着丝粒染色体+中心环（dic+r）和胞质分裂阻滞微核（CBMN）的风险高于血管畸形儿童。患者越年轻，IPs 后发生 CA 的风险就越大。此外，IPs后有5名儿童（约10%）发现了流氓细胞（RCs），且dic+r和CBMN的比率显着高于其他儿童（Z = -3.576，p < 0.001 ）  。这些结果表明，可能有一些患有VA的儿童对IR特别敏感，但未来需要更多的数据和更深入的实验来验证这一点。