Visceral pain (VP) is caused by internal organ disease. VP is involved in nerve conduction and related signaling molecules, but its specific pathogenesis has not yet been fully elucidated. Currently, there are no effective methods for treating VP. The role of P2X2/3 in VP has progressed. After visceral organs are subjected to noxious stimulation, cells release ATP, activate P2X2/3, enhance the sensitivity of peripheral receptors and the plasticity of neurons, enhance sensory information transmission, sensitize the central nervous system, and play an important role in the development of VP. However, antagonists possess the pharmacological effect of relieving pain. Therefore, in this review, we summarize the biological functions of P2X2/3 and discuss the intrinsic link between P2X2/3 and VP. Moreover, we focus on the pharmacological effects of P2X2/3 antagonists on VP therapy and provide a theoretical basis for its targeted therapy.

内脏痛（VP）是由内脏器官疾病引起的。VP参与神经传导及相关信号分子，但其具体发病机制尚未完全阐明。目前，尚无治疗VP的有效方法。P2X2/3 在 VP 中的作用已经取得进展。内脏器官受到伤害性刺激后，细胞释放ATP，激活P2X2/3，增强外周受体的敏感性和神经元的可塑性，增强感觉信息传递，使中枢神经系统敏感，在神经系统发育中发挥重要作用。副总裁。然而，拮抗剂具有缓解疼痛的药理作用。因此，在这篇综述中，我们总结了P2X2/3的生物学功能，并讨论了P2X2/3与VP之间的内在联系。此外，我们重点研究P2X2/3拮抗剂对VP治疗的药理作用，为其靶向治疗提供理论依据。