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Myroides odoratimimus: A New Threat with Persistent infections, Multidrug Resistance, and the Potential for Hospital Outbreaks
Japanese Journal of Infectious Diseases ( IF 2.2 ) Pub Date : 2023-06-30 , DOI: 10.7883/yoken.jjid.2023.005
Ismail Selcuk Aygar 1 , Canset Nur Aydogan 2 , Hande Ozcan 2 , Irem Unat 2 , Tugba Fatsa 3 , Kemal Tekin 1 , Aysun Yalci 4 , Tugrul Hosbul 2 , Fatih Sahiner 2 , Ramazan Gumral 2
Affiliation  

Myroides species, are reported more frequently as outbreaks in clinics and intensive care units (ICUs). In this study, it is aimed to investigate the epidemic potential, antibiotic resistance profile and risk factors of the M. odoratimimus isolates, are increasingly isolated in the intensive care units (ICUs) of our hospital. Data of patients, whose Myroides spp. were isolated in their clinical specimens, over a five-year period (September 2016-January 2022) were retrospectively analyzed. Identification of bacteria were performed with the Matrix: Assisted Laser Desorption Ionization/Time of Flight-Mass Spectrometer (MALDI-TOF MS) System. The presence of antibiotic resistance genes were analyzed by polymerase chain reaction (PCR) method. Possible clonal association between isolates was investigated the Enterobacterial Repetitive Intergenic Consensus (ERIC)-PCR method. 66 isolates were identified as M. odoratimimus and one isolate as M. odoratus. The presence of the blaMUS resistance gene was detected in all M. odoratimimus isolates, while the presence of sul2 in 10 isolates and tetX in 11 isolates was detected. Other resistance genes, including blaTUS, were not detected. Also 2 different clonal association patterns were found in 24 selected isolates by (ERIC)-PCR method.The increase in the immunosuppressive patient population point to the possibility of encountering this agent and other opportunistic pathogens more frequently in the future.



中文翻译:

Myroides odoratimimus:一种具有持续感染、多重耐药性和医院爆发可能性的新威胁

据报道, Myroides物种在诊所和重症监护病房 (ICU) 中更常爆发疫情。本研究旨在调查在我院重症监护病房 (ICU) 中越来越多分离出的拟臭莫拉氏菌分离株的流行潜力、抗生素耐药性和危险因素。Myroides spp患者的数据。从他们的临床标本中分离出来,对五年期间(2016年9月至2022年1月)进行回顾性分析。使用基质辅助激光解吸电离/飞行时间质谱仪 (MALDI-TOF MS) 系统进行细菌鉴定。通过聚合酶链反应(PCR)方法分析抗生素抗性基因的存在。采用肠杆菌重复基因间一致性 (ERIC)-PCR 方法研究了分离株之间可能的克隆关联。66株被鉴定为M. odoratimimus,1株为M. odoratus在所有拟臭味霉分离株中均检测到bla MUS抗性基因的存在,同时在 10 个分离株中检测到sul2,在 11 个分离株中检测到tetX 。没有检测到其他抗性基因,包括bla TUS 。此外,通过 (ERIC)-PCR 方法在 24 个选定的分离株中发现了 2 种不同的克隆关联模式。免疫抑制患者群体的增加表明未来可能更频繁地遇到这种病原体和其他机会性病原体。

更新日期:2023-06-30
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