The World Health Organization has acknowledged the gap in schizophrenia diagnoses and recommended further research to identify tools and biomarkers for the disease’s early detection. Because the skin and brain have a common ectodermal origin, dermatoglyphics are hypothesized to serve as a potential mirror for the identification of risks and characteristics of neuropsychiatric diseases. This study aimed to determine the digito-palmar dermatoglyphic patterns of schizophrenia patients in Ghana. Digito-palmar dermatoglyphics were obtained using a digital scanner, and the details studied. Individuals living with schizophrenia in Ghana were significantly characterized by low odds of vestige pattern in the hypothenar region, low odds of palmar creases 300, and high and low odds of radial loop (RL) and plain arch (PA) respectively at the finger patterns relative to the control group [OR (95% CI): vestige, 0.2 (0.06–0.69), P = 0.01; palmar creases 300, 0.1 (0.01–0.99), P = 0.049; PA, 0.4 (0.3–0.7), P < 0.001; RL, 1.9 (1.0–3.7), P = 0.044]. Individuals with schizophrenia were also characterized by low mean left-hand a-b ridge count and mean right hand atd angle compared to controls. These differences could be explored as a potential biomarker in diagnosing and early detection of schizophrenia in Ghanaians.

世界卫生组织已经承认精神分裂症诊断方面的差距，并建议进一步研究以确定该疾病早期检测的工具和生物标志物。由于皮肤和大脑具有共同的外胚层起源，因此皮纹被假设为识别神经精神疾病的风险和特征的潜在镜子。本研究旨在确定加纳精神分裂症患者的指掌皮纹模式。使用数字扫描仪获得指掌皮纹，并研究细节。加纳精神分裂症患者的显着特征是小鱼际区域残留图案的几率较低，手掌折痕的几率较低300，P  =0.01；手掌折痕 300, 0.1 (0.01–0.99), P  = 0.049; PA，0.4（0.3–0.7），P  < 0.001；RL，1.9（1.0–3.7），P  = 0.044]。与对照组相比，精神分裂症患者的平均左手脊数和平均右手 atd 角也较低。这些差异可以作为加纳人精神分裂症诊断和早期检测的潜在生物标志物进行探索。