Abstract

Silicone implants are widely used for plastic or reconstruction medical applications. However, they can cause severe infections of inner tissues due to bacterial adhesion and biofilm growth on implant surfaces. The development of new antibacterial nanostructured surfaces can be considered as the most promising strategy to deal with this problem. In this article, we studied the influence of nanostructuring parameters on the antibacterial properties of silicone surfaces. Nanostructured silicone substrates with nanopillars of various dimensions were fabricated using a simple soft lithography technique. Upon testing of the obtained substrates, we identified the optimal parameters of silicone nanostructures to achieve the most pronounced antibacterial effect against the bacterial culture of Escherichia coli. It was demonstrated that up to 90% reduction in bacterial population compared to flat silicone substrates can be achieved. We also discussed possible underlying mechanisms behind the observed antibacterial effect, the understanding of which is essential for further progress in this field.

摘要

硅胶植入物广泛用于整形或重建医疗应用。然而，由于种植体表面的细菌粘附和生物膜生长，它们可能导致内部组织的严重感染。新型抗菌纳米结构表面的开发可以被认为是解决这一问题的最有前途的策略。在本文中，我们研究了纳米结构参数对有机硅表面抗菌性能的影响。使用简单的软光刻技术制造了具有不同尺寸纳米柱的纳米结构有机硅基底。通过对所获得的基材进行测试，我们确定了有机硅纳米结构的最佳参数，以实现对大肠杆菌细菌培养物最显着的抗菌效果。事实证明，与平面有机硅基材相比，细菌数量最多可减少 90%。我们还讨论了观察到的抗菌作用背后可能的潜在机制，了解这一机制对于该领域的进一步进展至关重要。