Involvement of AKT/PI3K Pathway in Sanguinarine's Induced Apoptosis and Cell Cycle Arrest in Triple-negative Breast Cancer Cells.,Cancer Genomics & Proteomics

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Involvement of AKT/PI3K Pathway in Sanguinarine's Induced Apoptosis and Cell Cycle Arrest in Triple-negative Breast Cancer Cells.
Cancer Genomics & Proteomics ( IF 2.5 ) Pub Date : 2023-7-4 , DOI: 10.21873/cgp.20385
Samia S Messeha _{1,

2} , Sophie Noel _{1,

2} , Najla O Zarmouh ₃ , Tracy Womble ₁ , Lekan M Latinwo ₂ , Karam F A Soliman ₄

Affiliation

Chemotherapy resistance in triple-negative breast cancer (TNBC) cells is well documented. Therefore, it is necessary to develop safer and more effective therapeutic agents to enhance the outcomes of chemotherapeutic agents. The natural alkaloid sanguinarine (SANG) has demonstrated therapeutic synergy when coupled with chemotherapeutic agents. SANG can also induce cell cycle arrest and trigger apoptosis in various cancer cells.

中文翻译：

AKT/PI3K 通路参与血根碱诱导的三阴性乳腺癌细胞凋亡和细胞周期停滞。

三阴性乳腺癌（TNBC）细胞的化疗耐药性已有充分记录。因此，有必要开发更安全、更有效的治疗药物来提高化疗药物的疗效。天然生物碱血根碱 (SANG) 与化疗药物联合使用时已显示出治疗协同作用。SANG 还可以诱导细胞周期停滞并引发各种癌细胞的凋亡。

更新日期：2023-07-04

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