Purpose:
To report the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for macroscopic histologically confirmed local relapse of prostatic cancer after prostatectomy and subsequent external irradiation.

Material and methods:
A retrospective study of patients with prostate adenocarcinoma, treated with HDR-IRT for an isolated local relapse after prostatectomy and external irradiation at our institution (2010-2020). Treatment results and treatment related-toxicity were recorded. Clinical outcomes were analyzed.

Results:
Ten patients were identified. The median age was 63 years (range, 59-74 years), and the median follow-up time was 34 months (range, 10-68 months). Four patients had a biochemical relapse, and the mean time to prostate specific antigen (PSA) increase was 13 months. One-year biochemical failure-free survival (bFFS), 3-year bFFS, and 4-year bFFS were 80%, 60%, and 60%, respectively. Most of the treatment-related toxicities were grade 1-2. Two patients experienced grade 3 late genitourinary toxicity.

Conclusions:
HDR-IRT seems to be an effective treatment option showing acceptable toxicity for prostate cancer patients with isolated macroscopic histologically confirmed local relapse after prostatectomy and subsequent external irradiation.



中文翻译：

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根治性前列腺切除术和随后的外部照射后局部复发前列腺癌的挽救性高剂量率介入放射治疗（近距离放射治疗）

目的：
报告使用高剂量率（HDR）介入放射治疗（近距离放射治疗，IRT）作为前列腺切除术和随后的外部照射后肉眼组织学证实的前列腺癌局部复发的挽救治疗。

材料和方法：
对前列腺腺癌患者进行的一项回顾性研究，这些患者在我们机构（2010-2020 年）接受 HDR-IRT 治疗，以治疗前列腺切除术和外部照射后的孤立性局部复发。记录治疗结果和治疗相关毒性。分析临床结果。

结果：
已确定十名患者。中位年龄为 63 岁（范围为 59-74 岁），中位随访时间为 34 个月（范围为 10-68 个月）。4 名患者出现生化复发，前列腺特异性抗原 (PSA) 增加的平均时间为 13 个月。一年生化无失败生存率 (bFFS)、3 年 bFFS 和 4 年 bFFS 分别为 80%、60% 和 60%。大多数与治疗相关的毒性为 1-2 级。两名患者出现 3 级晚期泌尿生殖毒性。

结论：
HDR-IRT 似乎是一种有效的治疗选择，对于在前列腺切除术和随后的外部照射后经宏观组织学证实局部复发的前列腺癌患者显示出可接受的毒性。