The transsulfuration pathway (TSP) is a metabolic pathway involving sulfur transfer from homocysteine to cysteine. Transsulfuration pathway leads to many sulfur metabolites, principally glutathione, H2S, taurine, and cysteine. Key enzymes of the TSP, such as cystathionine β-synthase and cystathionine γ-lyase, are essential regulators at multiple levels in this pathway. TSP metabolites are implicated in many physiological processes in the central nervous system and other tissues. TSP is important in controlling sulfur balance and optimal cellular functions such as glutathione synthesis. Alterations in the TSP and related pathways (transmethylation and remethylation) are altered in several neurodegenerative diseases, including Parkinson’s disease, suggesting their participation in the pathophysiology and progression of these diseases. In Parkinson’s disease many cellular processes are comprised mainly those that regulate redox homeostasis, inflammation, reticulum endoplasmic stress, mitochondrial function, oxidative stress, and sulfur content metabolites of TSP are involved in these damage processes. Current research on the transsulfuration pathway in Parkinson’s disease has primarily focused on the synthesis and function of certain metabolites, particularly glutathione. However, our understanding of the regulation of other metabolites of the transsulfuration pathway, as well as their relationships with other metabolites, and their synthesis regulation in Parkinson´s disease remain limited. Thus, this paper highlights the importance of studying the molecular dynamics in different metabolites and enzymes that affect the transsulfuration in Parkinson’s disease.

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转硫途径：帕金森病的靶向神经调节剂

转硫途径（TSP）是涉及硫从同型半胱氨酸转移到半胱氨酸的代谢途径。转硫途径产生许多硫代谢物，主要是谷胱甘肽、H2S、牛磺酸和半胱氨酸。TSP 的关键酶，例如胱硫醚 β-合酶和胱硫醚 γ-裂解酶，是该途径多个层面的重要调节因子。TSP 代谢物与中枢神经系统和其他组织的许多生理过程有关。TSP 对于控制硫平衡和优化细胞功能（例如谷胱甘肽合成）非常重要。TSP 和相关途径（转甲基化和再甲基化）的改变在包括帕金森病在内的几种神经退行性疾病中发生改变，表明它们参与了这些疾病的病理生理学和进展。在帕金森病中，许多细胞过程主要包括调节氧化还原稳态、炎症、网状内质应激、线粒体功能、氧化应激和TSP的硫含量代谢物的那些损伤过程。目前对帕金森病转硫途径的研究主要集中在某些代谢物，特别是谷胱甘肽的合成和功能上。然而，我们对转硫途径其他代谢物的调节、它们与其他代谢物的关系以及它们在帕金森病中的合成调节的理解仍然有限。因此，本文强调了研究影响帕金森病转硫作用的不同代谢物和酶的分子动力学的重要性。