Many degenerative disorders have started to develop as a result of the deposition of insoluble protein fibrillar clumps known as amyloid. This deposition mostly limits normal cellular function and signaling. This build-up of amyloid in vivo results in a variety of illnesses in the body, including type 2 diabetes, several neurodegenerative diseases (such as Alzheimer's disease and spongiform encephalopathy), and Alzheimer's disease. Growing interest has been demonstrated in nanoparticles as a potential treatments for amyloidosis throughout the past few decades. Inorganic nanoparticles are one of them and have also been in substantial research as a potential anti-amyloid drug. Inorganic nanoparticles have emerged as a good study candidates because of their nano size, distinctive physical characteristics, and capacity to traverse the blood-brain barrier. In the current review, we have focused on the effects of different types of inorganic nanoparticles on amyloidogenesis and attempted to understand their underlying mechanism of action.

中文翻译：

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无机纳米粒子作为淀粉样蛋白生成有效调节剂的综合综述

许多退行性疾病是由于称为淀粉样蛋白的不溶性蛋白质纤维团块的沉积而开始发展的。这种沉积主要限制正常的细胞功能和信号传导。体内淀粉样蛋白的积累会导致体内多种疾病，包括 2 型糖尿病、几种神经退行性疾病（如阿尔茨海默病和海绵状脑病）和阿尔茨海默病。在过去的几十年里，人们对纳米粒子作为淀粉样变性的潜在治疗方法越来越感兴趣。无机纳米颗粒就是其中之一，并且作为潜在的抗淀粉样蛋白药物也已进行了大量研究。无机纳米颗粒因其纳米尺寸、独特的物理特性、以及穿越血脑屏障的能力。在当前的综述中，我们重点关注不同类型的无机纳米颗粒对淀粉样蛋白生成的影响，并试图了解它们的潜在作用机制。