Cassiae semen has been shown to play significant roles in reversing “liver fire” to improve vision. The systems mechanism of Cassiae semen for hepatoprotection and brightening eyes has not been fully explored. The systems pharmacology approach is proposed to dissect the potential pharmacological mechanism of Cassiae semen for hepatoprotection and brightening eyes. The results showed that 26 active components of Cassiae semen that connected with 230 targets were obtained. Gene ontology enrichment, network and pathway analysis explored that Cassiae semen is responsible for hepatoprotection and brightening eyes. The current study will contribute to the research and development of functional foods.

决明子已被证明在逆转“肝火”以改善视力方面发挥着重要作用。决明子保肝明目的系统机制尚未完全阐明。提出系统药理学方法来剖析决明子保肝明目的潜在药理机制。结果表明，获得了决明子中26个活性成分，与230个靶标连接。基因本体富集、网络和通路分析揭示决明子具有保肝明目作用。目前的研究将有助于功能食品的研究和开发。