The synthesis and characterization of a novel hexacoordinated compound as a product of the reaction between chlorodimethylesterprotoprphyrin–Fe(III) 1 and 2–methylpiridine (2–CH₃Py) was performed. The [bis(o–methylpyridino)(dimethylesterprotoporphyrinato)Fe(III)] chloride 2 is a compound of the family of the pinch–porphyrins, a model of peroxidase enzymes. We analyzed 2 using UV-Vis, ¹H NMR, and EPR spectroscopies, as well as kinetic quantifications of its peroxidase activity and computational analysis, to evaluate the presence of the pinch-ligand coordinated to 1 in a series of pinch-ironprotoporphyrin complexes, as previously reported. Our investigation revealed that the oxidant activity of Compound I derived from peroxidase activity determination of 1 and 2, respectively, is better controlled when a heterohydrocarbonated chain is attached to the pyridyl groups that coordinate axially to 1; an effect evidenced by a decrease of the activation energy value associated with Compound 0 formation during the reaction performed by pinch–porphyrin, with the picdien axial ligand and hydrogen peroxide. When correlating the contribution of $s=$3/2 in the quantum mixed-spin state (qms), $s=$3/2, $s=$5/2, of iron(III)-based complexes with their peroxidase activity, we found that when the qms $s=$3/2, $s=$5/2, of iron(III) had 80% character $s=$3/2, the peroxide activity increased significantly. This could be a fundamental trait that could affect the peroxidase activity owing to the distortion of the iron geometry associated with its coordination number when $o--$methylpyridine is used as an axial ligand.

进行了一种新型六配位化合物的合成和表征，该化合物是氯二甲酯原卟啉-Fe(III) 1和2-甲基吡啶(2-CH ₃ Py)之间反应的产物。[双(邻甲基吡啶基)(二甲基酯原卟啉)Fe(III)]氯化物2是捏卟啉家族的化合物，是过氧化物酶的模型。我们使用 UV-Vis、¹ H NMR 和 EPR 光谱以及过氧化物酶活性的动力学定量和计算分析对 2 进行了分析，以评估与1配位的夹缩配体的存在。如先前报道的，在一系列夹断-铁原卟啉复合物中。我们的研究表明，当杂烃链连接到与1轴向配位的吡啶基上时，分别由1和2的过氧化物酶活性测定得出的化合物 I 的氧化活性得到更好的控制；在捏卟啉、picdien 轴向配体和过氧化氢进行反应期间，与化合物 0 形成相关的活化能值降低证明了这一效应。当关联贡献时$s=$3/2 处于量子混合自旋态 (qms)，$s=$3/2,$s=$5/2，铁（III）基复合物及其过氧化物酶活性，我们发现当 qms$s=$3/2,$s=$5/2, 铁(III)有80%的特性$s=$3/2时，过氧化物活性显着增加。这可能是一个基本特征，由于与其配位数相关的铁几何形状的扭曲，可能会影响过氧化物酶活性。$哦--$甲基吡啶用作轴向配体。